In the recent years, mass spectrometry-based proteomics has provided scientists with the tremendous capability to study plants more precisely than previously possible. Currently, proteomics has been transformed from an isolated field into a comprehensive tool for biological research that can be used to explain certain biological functions. Several studies have successfully incorporated the power of proteomics as a discovery tool to uncover plant resistance mechanisms. There is growing evidence which indicates that the spatial proteome and post translational modifications (PTMs) of proteins directly participate in the plant immune response.